weal-and-flare

weal-and-flare

Dictionary of molecular biology. 2004.

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  • flare — 1. A gradual tapering or spreading outward. 2. A diffuse redness of the skin extending beyond the local reaction to the application of an irritant; it is due to dilation of the arterioles and capillaries; depends upon an axon reflex set up by the …   Medical dictionary

  • mast cell — Resident cell of connective tissue that contains many granules rich in histamine and heparan sulphate. Release of histamine from mast cells is responsible for the immediate reddening of the skin in a weal and flare response. Very similar to… …   Dictionary of molecular biology

  • Skin prick test — A test of IgE related allergy involving pricking through the suspect allergen into the epidermis of the skin and observing for an immediate hypersensitivity response. This includes: itching, erythema, weal and flare response. It is a diagnostic… …   Wikipedia

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  • Histamine — Substance that plays a major role in many allergic reactions. Histamine dilates blood vessels and makes the vessel walls abnormally permeable. * * * A vasodepressor amine derived from histidine by histidine decarboxylase and present in ergot and… …   Medical dictionary

  • histamine — n. a compound derived from the amino acid histidine. It is found in nearly all tissues of the body, associated mainly with the mast cells. Histamine has pronounced pharmacological activity, causing dilation of blood vessels and contraction of… …   The new mediacal dictionary

  • triple response — The vascular changes in the skin in response to mild mechanical injury, an outward spreading zone of reddening (flare) followed rapidly by a weal (swelling) at the site of injury. Redness, heat, and swelling, three of the ‘cardinal signs’ of… …   Dictionary of molecular biology

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